[Frontiers in Bioscience 12, 125-134, January 1, 2007] 125 Genetic determinants of mammalian pituitary morphogenesis
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چکیده
1. Abstract 2. Introduction 3. Function and Development of the Pituitary Gland 3.1. Murine pituitary development 3.2. Pituitary development in humans 4. Induction and morphogenesis of Rathke’s Pouch 4.1. Origin of the pituitary primordium 4.2. BMP4 is essential for induction of RP 4.3. Opposing BMP and FGF gradients specify pituitary progenitors and pattern RP. 4.4. Sonic hedgehog signalling promotes proliferation of RP progenitors 4.5. Wnt Signalling is essential for RP development 5. Transcriptional control of progenitor cell differentiation 5.1. Lhx3 and Lhx4 5.2. Pitx1 and Pitx2 5.3. Hesx1 5.4. Prop1 5.5. Pit1 5.6. TPit 5.7. Sox3 6. Folliculo-stellate cells and adult progenitors 7. Summary and Perspective 8. Acknowledgement 9. References
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